My creatinine is borderline anyways (I am diabetic) and is usually around 1.5 to 1.6. When I use the NSAIDs though it will jump up to around 2.2 which really wouldn't be that much of an issue if it was not for the other meds I take specifically my BP med. That's how I catch it really, when I notice my blood pressure tanking. Actually had to stop my BP med for two days and majorly watch my sugar levels until things normalized. This would happen even with taking in 2 quarts of water per day.